Lopid is similar to fenofibrate (Tricor) and a fibric acid derivative. It acts reducing triglycerides and increasing cholesterol carried in high density lipoprotein thus decreasing risk of atherosclerosis, stroke, heart attack. Mechanism of its action is not known. Lopid is especially good in treatment of high cholesterol and triglyceride levels in patients with pancreatitis.
Dosage and direction
The recommended dose is 600 mg 30 minutes taken twice daily: before breakfast and dinner.
Follow all instructions of your doctor about diet, exercise routine, and weigh control mechanisms, as this medication is only a part of the treatment. Avoid consumption of food which is rich with cholesterol or fats. Regular monitoring of your blood fat is needed on a regular basis. Your doctor may demand regular examination of your kidney or liver function. Inform your doctor if you have liver disease, gallbladder disease, severe kidney disease.
Lopid is contraindicated in individuals with allergic reaction to gemfibrozil, liver disease, gallbladder disease, severe kidney disease, or when co-administered with repaglinide (Prandin).
Possible side effect
Immediate medical help is required if you feel sharp pain in your upper stomach after the intake of Lopid or eating, jaundice, blurred vision, painful urination, eye pain, seeing halos around lights.
Risk of rhabdomyolysis (muscle injury) increases when gemfibrozil is used with the statin family of cholesterol-reducing medications: pravastatin (Pravachol), lovastatin (Mevacor), rosuvastatin (Crestor), simvastatin (Zocor), fluvastatin (Lescol), and atorvastatin (Lipitor). When this condition is severe it may result in serious kidney damage and death. Concomitant use of these medications is not recommended, symptoms of rhabdomyolysis may appear in three weeks or several months after co-administration. Concomitant use with warfarin increases bleeding and requires correction of warfarin doses. Blood levels of repaglinide (Prandin) are increased by Lopid in patients with diabetes.
Cholestyramine (Questran) and Colestipol (Colestid) reduce effects of Lopid when co-administered. Lopid should be administered an hour before or 4-6 hours after intake of cholestyramine or colestipol.
If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended doses. Take your usually dose next day in the same regularly time.
Symptoms of overdose are: nausea, diarrhea, vomiting, stomach cramps, joint or muscle pain. Seek immediate medical attention if you experience these symptoms.
Store at room temperature between 20-25 C (68-77 F).