Leukeran is a medication used to treat several kinds of cancer and other conditions including Hodgkin’s disease (a type of lymphoma), malignant lymphoma (including lymphosarcoma), clasmocytoma, chronic lymphocytic leukemia, giant follicular lymphoma, hairy cell leukemia (a sub-type of chronic lymphoid leukemia), myeloma, ovarian cancer, breast cancer, Waldenstr?m macroglobulinemia (lymphoplasmacytic lymphoma), Letterer-Siwe disease (genetically stipulated proliferation of histiocytes), chorionepithelioma of the uterus, glomerular nephritis, Beh?et disease (a form of vasculitis), dermatomyositis, rheumatoid arthritis, sarcoidosis, uveitis, nephrotic syndrome. Leukeran’s active substance is chlorambucil, a bifunctional alkylating agent.
Dosage and direction
Take exactly as prescribed by your doctor. Follow all instructions. The recommended initial dosage for short course of treatment is 0.1 to 0.2 mg/kg body weight (4-10 mg for an average patient) taken daily during 3-6 weeks. The daily dose may be taken as a single dose. In case of the sudden fall in th white blood count or bad tolerance by the patient the dosage should be carefully adjusted. Supporting course of treatment is administered individually.
Carefulness should be exercised in the patients with inhibited bone marrow function (expressed as leukopenia, thrombocytopenia, and anemia, including ones associated with a malignant process and on the background of the previous radiotherapy or chemotherapy), severe liver disease and kidney failure, acute gastrointestinal disease, in pregnant and breastfeeding women. Blood cell count,leukocytes count, platelets count, and Hb examination should be performed at least once weekly.
Leukeran cannot be used in the patients with hypersensitivity to its components (including other alkylating agents).
Possible side effect
The most common side effects are nausea, vomiting, changes in menstrual period. Contact your doctor immediately if you have following adverse reactions: painful or difficult urination, fever, chills, black, tarry or bloody stools, easy bruising or bleeding, blood in urine, swollen extremities, sores in mouth or on lips, small red spots on the skin, jaundice, cough, lower back or side pain, joint pain, abdominal pain, confusion, hallucinations, muscle twitching, agitation, trouble walking, weakness, paralysis.
Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you use.
If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. Skip the missed dose if it is almost time of your next dose. Do not try to compensate a missed dose by taking an extra one.
If you suspect overdose inform your doctor immediately about it and seek immediate medical attention. Signs of overdose are agitation, seizures, loss of balance or coordination.
Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets. Do not use after expiration term.